Sperm cell at fertilization

Summary Mammalian fertilization begins when the head of a sperm binds in a species-specific manner to the zona pellucida surrounding the egg. A man may have a low sperm count, low sperm motility, sperm with an unusually high percentage of morphological abnormalities, or sperm that are incapable of penetrating the zona pellucida of an egg.

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If a fertilized egg ended up with two mutated copies of a recessive gene, the resulting embryo might die early in development.

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